Efecto hipoglucemiante del extracto hidroalcohólico de hojas de Muehlenbeckia volcanica (Benth.) Endl. “Mullaca” en ratas albinas
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Universidad Privada de Huancayo Franklin Roosevelt
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La investigación tuvo como objetivo evaluar el efecto hipoglucemiante del extracto hidroalcohólico de hojas de Muehlenbeckia volcanica “mullaca” en ratas albinas. Se realizó un estudio aplicado, experimental, prospectivo y longitudinal con 500 g de hojas de Zurite, Cusco, y 25 ratas distribuidas en cinco grupos. Se midió la glucosa basal y a 1, 3 y 6 horas, identificándose compuestos fenólicos, flavonoides y taninos. Las dosis de 500 y 750 mg/kg produjeron efectos hipoglucemiantes de 17,82 % y 33,46 %, respectivamente, frente al 45,40 % de la insulina (p < 0,001). Se concluyó que el extracto presentó efecto hipoglucemiante, siendo mayor a 750 mg/kg, aunque inferior al de la insulina.
The study aimed to evaluate the hypoglycemic effect of the hydroalcoholic extract of *Muehlenbeckia volcanica* ("mullaca") leaves in albino rats. An applied, experimental, prospective, and longitudinal study was conducted using 500 g of leaves from Zurite, Cusco, and 25 rats distributed into five groups. Basal glucose levels and levels at 1, 3, and 6 hours were measured, and phenolic compounds, flavonoids, and tannins were identified. Doses of 500 and 750 mg/kg produced hypoglycemic effects of 17.82% and 33.46%, respectively, compared to 45.40% for insulin (p < 0.001). It was concluded that the extract exhibited a hypoglycemic effect—greatest at the 750 mg/kg dose—although it was lower than that of insulin.
The study aimed to evaluate the hypoglycemic effect of the hydroalcoholic extract of *Muehlenbeckia volcanica* ("mullaca") leaves in albino rats. An applied, experimental, prospective, and longitudinal study was conducted using 500 g of leaves from Zurite, Cusco, and 25 rats distributed into five groups. Basal glucose levels and levels at 1, 3, and 6 hours were measured, and phenolic compounds, flavonoids, and tannins were identified. Doses of 500 and 750 mg/kg produced hypoglycemic effects of 17.82% and 33.46%, respectively, compared to 45.40% for insulin (p < 0.001). It was concluded that the extract exhibited a hypoglycemic effect—greatest at the 750 mg/kg dose—although it was lower than that of insulin.
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